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FREE RADICAL SCAVENGING ACTIVITY AND ANTIOXIDANT POTENTIAL OF THE MEDICINAL PLANT, moringa oleifera.



Okediran A.P., Adeyemo O.E., Banjoko K.I. on 06/01/2017

The phytochemical analysis of the medicinal plant Moringa Oleifera   was carried out to evaluate its antioxidant potential. Alcoholic and aqueous extracts of the leaves were subjected to in vitro antioxidant activity screening models such as inhibition of metal ion chelating activity, DPPH and ABTS scavenging activity. EDTA is used as a standard for metal ion chelating activity, Ascorbic acid is used as a standard. It can be  deduced  from  the  results obtained  that  the   leaf  extracts of Moringa Oleifera  contains antioxidants capable of protecting  normal  cells  from  oxidative  death,  while  rendering  the  cancer  cells  more  susceptible  to the cytotoxic action of the chemotherapeutic drug, etoposide, suggesting that the leaves of this plant can be administered as a  supportive therapy during cancer  chemotherapy,  to  minimize  the  toxic  side  effects  to  non-cancerous  cells  and  to maximize the anticancer drug action. In all   the models studied, the extracts showed potent antioxidant activity, thereby augmenting it into the present day system of medicine.

Key words: Phytochemical, antioxidant potential, chelating activity, supportive therapy.